Zacualpan de Amilpas is a town in the Mexican state of Morelos. The town serves as the municipal seat for the surrounding municipality, with which it shares a name. To the north is the municipality of Tetela del Volcán, to the south is the municipality of Temoac, to the east is the State of Puebla, and to the west are the municipalities of Ocuituco and Yecapixtla.